犬のアトピー性皮膚炎に関与する抗原
永 田 雅 彦
| ASCどうぶつ皮膚病センター（〒182-0012 東京都調布市深大寺東町1-3-2） |
（1999年1月6日受付・1999年6月30日受理）
アトピー性皮膚炎（以下，AD）の犬60頭と --------------------日獣会誌 52，658〜660（1999）
Responses to Antigens in Dogs with Atopic DermatitisMasahiko NAGATA
SUMMARY Intradermal skin tests (IDST) and measurements of allergen-specific IgE antibodies (serologic tests)
were performed on 60 dogs with atopic dermatitis (AD) and 53 pruritic dogs without AD. Dogs with AD showed
positive reactions to fleas in 40.0% of cases examined, to house dust mites (mites) in 96.7%, and to
pollen in 18.2%. Serologic tests on the same animals produced positive reactions to fleas in 13.3% of
all cases, to mites in 83.3%, and to pollen in 33.3%. IDST on pruritic dogs without AD showed positive
reactions to fleas in 15.1% of all cases, to mites in 5.7%, and to pollen in 6.7%. Serologic tests on
the same animals showed positive reactions to fleas in 9.4% of all cases, to mites in 23.7%, and to pollen
in 6.7%. According to IDTS results, 85.5% of dogs with AD reacted positively to the mite Dermatophagoides
farinae (Df) and 29.6% to the mite Dermatophagoides pteronyssinus (Dp). Serologic tests showed that the
corresponding percentages were Df 83.3% and Dp 22.2%. According to the results of IDST, 7.9% of pruritic
dogs without AD, reacted positively to Df and 0% to Dp. The corresponding percentages were Df 23.7% and
Dp 7.9% in serologic tests. The findings of this study indicate that the mite is the most significant
antigen associated with canine AD and that Df is the most common variety in Japan. --------------------J. Jpn. Vet. Med. Assoc., 52, 658〜660(1999) |
痒を有する非AD犬53頭に皮内反応および血清特異IgE抗体測定（以下，血清検査）を実施した．AD犬の皮内反応陽性率はノミ40.0％，チリダニ（以下，ダニ）96.7％，花粉18.2％，血清検査陽性率はノミ13.3％，ダニ83.3％，花粉33.3％であった．非AD犬の皮内反応陽性率はノミ15.1％，ダニ5.7％，花粉6.7％，血清検査陽性率はノミ9.4％，ダニ23.7％，花粉6.7％であった．AD犬におけるダニ陽性抗原の内訳は，皮内反応がコナヒョウヒダニ（以下，Df）85.2％，ヤケヒョウヒダニ（以下，Dp）29.6％，血清検査がDf
83.3％，Dp 22.2％であった．非AD犬におけるダニ陽性抗原の内訳は，皮内反応がDf 7.9％，Dp 0％，血清検査がDf 23.7％，Dp 7.9％であった．本邦のAD犬に関与する抗原として，Dfを中心としたダニがきわめて重要であることが明らかになった．