犬の悪性末梢神経鞘腫瘍の1例

日本大学生物資源科学部（〒252-8510　藤沢市亀井野1866）

（1998年9月10日受付・1999年4月2日受理）

要　　　　　約 　犬（雑種，雌，17歳，体重7.5kg）の右眼後方に発生した腫瘤（径10×8×5cm）を病理学的に検索し，悪性末梢神経鞘腫瘍と診断した．腫瘤は紡錘形細胞に富む部分と，細胞密度が粗で粘液腫状の部分から構成され，紡錘形細胞の束状配列と多量の膠原線維がみられ，局所リンパ節に転移がみられた．一部の腫瘍細胞は免疫染色でS-100蛋白陽性を示し，電顕的には接着斑と核の著しい異型性が認められた． ―キーワード：犬，悪性末梢神経鞘腫瘍． --------------------日獣会誌　52，441〜443（1999） A Canine Case of Malignant Peripheral Nerve Sheath Tumor Hiroshi SUDO, Yuko HORIUCHI, Tsuneo SATO, Wataru SHIRAI and Hiroshi KOIE College of Bioresourse Sciences, Nihon University, 1866 Kameino, Fujisawa 252-8510, Japan SUMMARY 　A tumor mass 10×8×5cm in diameter, arising at the retrapolathalmic temporal region of a 17-year-old female mongrel dog, was examined histopathologically and diagnosed as malignant peripheral nerve sheath tumor. The mass consisted of solid proliferation of spindle-shaped neoplastic cells showing fascicular arrangement with some myxomatous stroma or abundant collagen deposit. Metastasis was seen in the local lymph nodes. Some tumor cells were immunohistochemically positive for S-100 protein, and electoron microscopy revealed the tumor cells had desmosomes and a severely atypical nucleus. ―Key words : dog, malignant peripheral nerve sheath tumor. --------------------J. Jpn. Vet. Med. Assoc., 52, 441〜443(1999)